NAD+ Brain Restoration Therapy

Medically reviewed by
Stephanie Klein, MSN, FNP-C

NAD Brain Restoration Therapy is the use of NAD+ supplementation to provide direct benefits to the brain, neurological system, and mitochondria of each cell.

Other Names:

NAD Infusion, Nicotinamide adenine dinucleotide


Biological, Anti-Aging

Helpful for:

Brain, Fatigue, Lyme Disease, Infectious Diseases, Emotional (Anxiety and Depression)

Created by:


Introduction to NAD Brain Restoration Therapy

NAD/Brain Restoration Plus (BR+) is a comprehensive and natural detox and nutrient-based treatment. Nicotinamide adenine dinucleotide (NAD) is a coenzyme found in all living cells and plays a crucial role in the chemical process that generates energy, especially in the brain.

The NAD/BR+ protocols help patients replenish their supply of neurotransmitters, improve cognitive functioning, withdraw from addictive substances, overcome anxiety, depression, chronic or acute stress, post-traumatic stress, CTE, and other conditions by giving the brain what it needs to return to proper functioning. These protocols are completely nutrient-based – not another drug to become addicted to or dependent upon. It is clear to see how important NAD is for the body as it is involved in every bodily function and catalyzes more than a thousand metabolic reactions in the organs and tissues.

NAD Brain Restoration (BR+) is a proprietary formula compounded by a state-of-the-art, FDA-regulated facility, that can only be found in a small number of medical offices in the world and requires special licensing and training. It is used both intravenously and as a nasal spray. Because of its role in energy production, NAD is also used for improving athletic endurance and combating fatigue.

Benefits of NAD BR+ Therapy

Many neurological disorders have been shown to be related to low NAD levels. By supplementing with NAD, the goal is to reverse and protect from the breakdown of vital neurological and brain functions.

Clinical experience has shown that NAD BR+ may be used for a number of brain related issues, and that the benefits include:

  • Replenishes balance of neurotransmitters in the brain
  • Optimizes mitochondrial function in the brain
  • Improves mental clarity and cognitive function (focus and concentration)
  • Accelerates the recovery of psycho-emotional issues following treatment of chronic conditions
  • Helps the cells convert food into energy by acting as an electron transporter during cell metabolism
  • Support the activation of PARPs (Poly ADP ribose polymerase), which detect and repair damaged DNA
  • Increases activity of a group of enzymes called sirtuins, which helps increase metabolism, decrease inflammation, extend cell life, and prevent neurodegeneration
  • Activates cell signaling: research is revealing that NAD and ATP may alert the immune response when the cell is under stress or when there is inflammation

NAD brain restoration therapy is also used as part of addiction treatment. NAD+ helps restore energy levels that were lowered during periods of substance abuse to assist in recovery.

How NAD Brain Restoration Therapy Works

NAD brain restoration works when using NAD to restore levels in the body. NAD BR+ uses the purest form of NAD to infuse NAD+ intravenously or use as a nasal spray. Intravenous infusion of NAD+ has shown to be one of the most effective ways to increase NAD+ levels.

Nicotinamide adenine dinucleotide (NAD) is an element that reacts with oxygen in the cell’s mitochondria in order to create energy for movement, breathing, heartbeat, blood pumping, digesting food, brain functions, and generally living life.

NAD enables the transfer of energy from the foods we eat to vital cell functions. It is also required to “turn off” genes that accelerate degenerative aging processes. As NAD+ levels decline, mitochondrial function is impaired, resulting in fewer mitochondria surviving. Mitochondria are the “powerhouses” that help ensure cellular processes. This vicious cycle of mitochondrial depletion (also called NAD Energy Deficiency, or NED) results in many of the physical symptoms of aging and degenerative processes, such as chronic fatigue syndrome, substance abuse, depression, stress, anxiety and various other chronic illnesses.

NAD Brain Restoration Therapy has the ability to provide the brain and body with NAD and a proprietary amino acid formula that reverses NAD and related dysfunctions. Through an intravenous infusion or via nasal spray, NAD BR+ has been shown to help the body produce ATP, protect and repair DNA, strengthen the immune system, lower cholesterol and blood pressure, and stimulate the production of dopamine, serotonin, and noradrenaline, thereby improving mood.

Prominent universities have been investigating NAD+ as a potential therapy for age-related degenerative disease. Compelling research shows that NAD+ has a unique ability to protect tissues, induce DNA repair, and increase life span. Studies done in the early 1960s demonstrated the efficacy and safety of IV NAD in detoxifying patients from alcohol, opiates, tranquilizers, and stimulants. Current research also indicates that NAD deficiencies may trigger a host of metabolic and degenerative diseases – including obesity, Type II diabetes, chronic traumatic encephalopathy, Alzheimer’s, and Parkinson’s. When using NAD with the BR+ protocols for addiction or stress treatment, neurochemical imbalances can be restored to healthy functioning usually within ten days or less.

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Behind the Science

Science & Safety

A study evaluating cognitive function using the Mini Mental Status Exam tool found NAD+ supplementation to improve scores. This study was limited in size (only 17 subjects) as well as lack of controls.

Another small study that did have a control group found verbal fluency to increase in patients with dementia (including Alzheimer’s Disease) who were treated with oral NAD+ therapy. Participants were also noted to have a decrease in the rate of cognitive decline.

There have been benefits shown in embryonic stem cells of mice in vitro which show promise in the treatment of Parkinson’s Disease using NAD brain restoration therapy. NAD was found to promote neuronal differentiation, a key action in reducing the proliferation and progression of Parkinson’s Disease.

While studies are limited, it’s been proven that metabolism and brain energy balance is altered in substance abuse. The fact NAD+ helps restore metabolism and facilitate the transfer of energy into cells makes it a compelling option when treating substance abuse disorders.


Where does NAD+ Brain Restoration Therapy fall on the medical spectrum?

NAD+ BR Therapy falls under ‘Alternative Medicine’ section of the medical spectrum.

Alternative Medicine

Also known as holistic medicine, it is the study and application of nature, botany, energy, and technology to bring the body back to balance and address the root causes of disease without detrimental side effects, toxins and chemicals, or a lifetime of intervention.

Biological Medicine

Also known as European Biological Medicine, this modality, popular in Germany and Switzerland, applies numerous therapies that aim to restore the body’s regulatory and self-healing capacity by promoting proper regeneration on a cellular and organ level.

Conventional Medicine

Conventional medicine is the most recognized and practiced section of the medical spectrum that includes pharmacological drugs, surgical procedures, lab testing, and more in an attempt to reduce symptoms and manage disease. 

Conventional Therapies

The Innovative Medicine approach considers all conventional options and appropriately prescribes or refers patients to specialists in which this approach would be most suited.

Emotional Therapies

Mental health and the study of mind-body medicine is an integral part of the medical spectrum that can often go overlooked and unaddressed.

Psycho-Emotional Intervention

The study of psycho-neuro-immunology (PNI) has shown how our thoughts and psychological state impact our biochemistry and can lead to disease. Any comprehensive treatment plan must address psychological stress to be successful.

Spiritual Practices & Therapies

We often confuse spiritual practices with religion, but the role of spirituality, consciousness, awareness, purpose, and information on a quantum level is incredibly important in healing.

Receiving Therapy

NAD BR+ Therapy Protocol – Receiving Treatments

The New York Center of Innovative Medicine (NYCIM) is happy to offer patients NAD Brain Restoration IV infusions. This proprietary formula requires special training and access to a compounding pharmacy that provides the high quality compound. However, the use of this or any of our numerous therapeutic options is only performed on patients after an in-depth health evaluation. Our ultimate goal is the complete restoration of health in the most efficient and safe manner, and with so many therapeutic options, it is impossible to know if NAD BR+ Therapy is right for you without an initial evaluation at our clinic.

More Info

Frequently Asked Questions

NAD Brain Restoration (BR+) is a proprietary formula compounded by a state-of-the-art, FDA-regulated facility, that can only be found in a small number of medical offices in the world and requires special licensing and training. It incorporates specific amino acids together with NAD+ with very high purity for enhanced effectiveness.

NAD brain restoration therapy uses the purest form available – NAD BR+ – to provide natural and safe benefits to the brain and overall neurological function by increasing circulation NAD+ levels in the body.

NAD brain restoration therapy is used to slow down the progression and treat neurological diseases like dementia and Parkinson’s Disease. NAD brain restoration therapy is also used to help treat addiction.

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NAD Brain Restoration Therapy

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