Ozone Therapy

Medically reviewed by
Stephanie Klein, MSN, FNP-C

Ozone therapy is a form of oxidative therapy used to increase oxygenation and support vital functions related to healing and overall cellular function.

Other Names:




Helpful for:

Infectious Diseases, Lyme Disease, Toxicity, Immunity, Fatigue, Cardiac Conditions, GI Issues, Cancer Support

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Introduction to Ozone Therapy

Ozone therapy is an effective therapeutic method to increase oxygenation, support detoxification, and stimulate the immune system. Ozone therapy uses ozone, which is a blue-colored form of oxygen, composed of three oxygen atoms instead of two. It’s the addition of the third oxygen atom that makes ozone “supercharged” oxygen and gives it all of its remarkable medical properties.

You may know of the presence of ozone as a natural component in our environment (think the smell after a lightning storm). But you may not know ozone is a powerful oxidizer and potentiator of human physiology stimulating all sorts of physiological activity.

Ozone therapy works by increasing oxygen use in turn assisting organ function, hormonal regulation, anti-aging, digestion, elimination, reproduction, memory, and many other functions.

The use of ozone to treat various medical conditions was first developed in Germany in the early 1950s.

Ozone use in medicine from a holistic understanding is based on the fact that toxins and pathogens in the body are normally destroyed by the process of oxidation. Oxidation breaks the toxins down into carbon dioxide and water and then eliminates them from the body. However, if the body is weak or deficient in oxygen, it can’t eliminate toxins adequately and a toxic reaction can occur. In minor cases, a toxic buildup can lead to fatigue, and a wide range of diseases can result when poor oxygenation is chronic.

Today, medical ozone therapy is common throughout European medical clinics, and its use has gradually been spreading in America over the last 25 years. This oxidative therapy is often administered for the support of all infectious diseases as well as chronic conditions such as chronic fatigue syndrome, arthritis, Alzheimer’s Disease, Multiple Sclerosis, dementia, fibromyalgia, heart disease, and many more.

Benefits of Ozone Therapy

Clinical experience has shown ozone therapy may be used for a number of conditions and issues. Benefits of ozone therapy include:

  • Inactivation of bacteria, viruses, and fungi
  • Enhancement of circulation
  • Stimulation of enzymatic activity and oxygen metabolism
  • Acceleration of glycolysis in red blood cells
  • Increase of tissue oxygenation
  • Increasing the release of O2 from hemoglobin in the blood to tissue
  • Enhancement of formation of acetyl CoA (vital for detoxification)
  • Increase of red blood cell pliability, blood fluidity, and arterial pO2
  • Stimulation of the reticuloendothelial systems, thus rebuilding tissue
  • Activation of the enzymes involved in peroxide or free radical destruction
  • Disruption of the lipid cell membranes of anaerobic pathogens and weak or defective cells

How Ozone Therapy Works

Ozone, referred to as O3, is a molecule consisting of three oxygen atoms. Because ozone is a relatively unstable molecule and will not last very long, it breaks down into more stable oxygen molecules. In biological systems, including the human body, ozone instantaneously interacts with double bonds found in amino acids and lipids to form peroxides.

These peroxides can easily penetrate cell membranes and increase oxygenation of intracellular compounds (NADH and FADH2) involved with energy production. In addition, ozone therapy stimulates the uptake of oxygen by stimulating the DPG enzyme, which supports the release of oxygen from hemoglobin molecules so it can be used by the cell.

When cells get the optimal amount of oxygen, they function properly and help to prevent or inhibit disease.

Ozone has the following actions:

  • Antiseptic / disinfectant
  • Bactericide / virucide / fungicide / parasiticide / parasiticide
  • Hemostat (assists with bleeding)
  • Analgesic (pain relief)
  • Circulatory stimulant
  • Wound cleansing/wound healing agent

Ozone performs these functions through ionization, subatomic exchange (oxidation), electron/free radical reactions, and electromagnetic reactions resulting in profuse photon and energy transfer.

More simply, because ozone is an oxygen molecule without an electron, it is attracted to electron-rich microorganisms. After it strips away the organisms’ electrons, the cause of the disease dies. Healthy human cells are not affected because they produce antioxidants making them impervious to ozone.

The most common method of ozone administration is intravenously (major autohemotherapy, minor autohemotherapy, or direct intra-arterial or intravenous injection), but may also be administered through:

  • Intramuscular injection
  • Intra-articular injections
  • Specific tissue injections
  • Local application to external body surfaces (transparent Teflon bags)
  • Rectal insufflation
  • Vaginal insufflation

Ozone injections are administered for just about every joint in our bodies, including elbows (tennis elbow), knees and hips, shoulders (rotator cuffs), ankles and fingers (arthritis), wrists (carpal tunnel), and essentially all cartilage and tendons found in the body.

Ozone therapy through intravenous administration is utilized through a machine, where blood is taken intravenously and passed through the specialized machine that infuses ozone into the blood at any given amount.

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Behind the Science

Science & Safety

Ozone therapy is used by more than 40,000 physicians in more than 50 countries, and its effects are proven and consistent, safe with minimal and preventable side effects.

A randomized controlled trial of 101 patients with type 2 diabetes and diabetic feet were treated with local and rectal insufflation of ozone gas. The other group received topical and systemic antibiotics to compare the benefits of the two treatments. Researchers found ozone therapy “improved glycemic control, prevented oxidative stress, normalized levels of organic peroxides, and activated superoxide dismutase”. Furthermore, the group treated with ozone therapy had fewer amputations than the control group. There were no side effects of ozone therapy. This trial concluded medical ozone treatment to be an effective and safe alternative treatment of diabetes and complications from diabetes.

Research from an international team of experts adds to the evidence that it does provide real relief from common forms of pain. The team pooled the results of 29 studies involving nearly 18,000 participants. Some had acupuncture, some had “sham” acupuncture, and some didn’t have acupuncture at all. Overall, acupuncture relieved the pain by about 50%.

A randomized trial showed oral administration of ozone therapy prior to a drug used to treat chronic pulmonary obstructive disease to be helpful in reducing neutrophil activation and recruitment. This study shows promise in the complimentary use of ozone therapy to treat neutrophil-dominant diseases.

Recent discoveries underline that ozone therapy could be an additional therapy for cancer patients receiving radio-chemotherapy. The use of ozone therapy enhances the action of chemotherapy and simultaneously reduces side-effects, such as nausea, vomiting, hair loss, and fatigue and many more. This can also result in a larger physical and mental wellbeing and improve one’s quality of life.


Where does Ozone Therapy fall on the medical spectrum?

Ozone therapy falls under ‘XXX’ section of the medical spectrum.

Alternative Medicine

Also known as holistic medicine, it is the study and application of nature, botany, energy, and technology to bring the body back to balance and address the root causes of disease without detrimental side effects, toxins and chemicals, or a lifetime of intervention.

Biological Medicine

Also known as European Biological Medicine, this modality, popular in Germany and Switzerland, applies numerous therapies that aim to restore the body’s regulatory and self-healing capacity by promoting proper regeneration on a cellular and organ level.

Conventional Medicine

Conventional medicine is the most recognized and practiced section of the medical spectrum that includes pharmacological drugs, surgical procedures, lab testing, and more in an attempt to reduce symptoms and manage disease. 

Conventional Therapies

The Innovative Medicine approach considers all conventional options and appropriately prescribes or refers patients to specialists in which this approach would be most suited.

Emotional Therapies

Mental health and the study of mind-body medicine is an integral part of the medical spectrum that can often go overlooked and unaddressed.

Psycho-Emotional Intervention

The study of psycho-neuro-immunology (PNI) has shown how our thoughts and psychological state impact our biochemistry and can lead to disease. Any comprehensive treatment plan must address psychological stress to be successful.

Spiritual Practices & Therapies

We often confuse spiritual practices with religion, but the role of spirituality, consciousness, awareness, purpose, and information on a quantum level is incredibly important in healing.

Receiving Therapy

Ozone Therapy Protocol – Receiving Treatments

The New York Center of Innovative Medicine (NYCIM) is pleased to offer ozone therapy at our clinic. However, the use of this or any of our numerous therapeutic options is only performed on patients after an in-depth health evaluation. Our ultimate goal is the complete restoration of health in the most efficient and safe manner, and with so many therapeutic options, it is impossible to know if ozone therapy is right for you without an initial evaluation at our clinic.

More Info

Resources & Experts

Frequently Asked Questions

Ozone therapy is an oxidative therapy consisting of administering ozone (O3) via various routes including intravenously to increase overall oxygenation in the body to help with detoxification, improve cellular function, and support the immune system.

Ozone therapy can be administered intravenously, intra-articularly, orally, topically, as well as several other ways.

Ozone therapy works by interacting with double bonds found in amino acids and lipids to form peroxides. These peroxides then penetrate the cell membranes and increase oxygenation to vital functions and tissues.

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Ozone Therapy

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